Medicinsk epidemiologi
Forskargruppen medicinsk epidemiologi finns i Epihubben, en arbetsplats och nätverk för epidemiologisk forksning inom Vetenskapsområdet medicin och farmaci, med lokaler i MTC-huset, Dag Hammarskjölds väg 14B (karta). Här samlas forskare från olika institutioner som ägnar sig åt epidemiologisk forskning. Ambitionen är att över forskargruppsgränserna utbyta erfarenheter och inspirera till nya forskningsprojekt och tillsammans bygga en långsiktig grund för avancerad epidemiologisk forskning.

Vårt huvudsakliga forskningsområde omfattar sjukdomar och tillstånd i den åldrande befolkningen, inklusive fragilitetsfrakturer, hjärt-kärlsjukdom och cancer, men vi är även involverade i andra epidemiologiska forskningsområden. Vi kombinerar traditionella epidemiologiska metoder med moderna metoder från området kausal inferens och applicerar dessa på observationsstuder. Vi utför även randomiserade interventionsstudier. Läs mer om vår forskning genom att titta igenom vår publikationslista.
SIMPLER
Karl Michaëlsson, forskargruppsledare för Medicinsk epidemiologi, är också föreståndare för den nationella infrastrukturen SIMPLER, Swedish Infrastructure for Medical Population-Based Life-Course and Environmental Research (simpler4health.se). Mycket av vår forskning baseras på kohorterna som ingår i SIMPLER. Sedan slutet av 2018 leds SIMPLER av ett konsortium bestående av Uppsala universitet, Karolinska institutet, Chalmers tekniska högskola och Örebro universitet, i samarbete med Region Uppsala, Västmanland och Örebro.
Infrastrukturen har till uppgift att förse nationella och internationella forskare med material för forskning om hur kost- och livsstilsfaktorer men också genetik påverkar vår hälsa under framför allt den senare delen av livet. Kunskapen kan användas för att till exempel utveckla råd och rekommendationer om kost och livsstil, utveckla nya markörer för att enklare och effektivare diagnostisera kroniska sjukdomar och dess förstadier och utveckla nya individanpassade behandlingsmetoder.
Finansiering
Forskargruppen har fått finansiering från Vetenskapsrådet, Forte, Hjärt-lungfonden, Cancerfonden, Hjärnfonden och ALF.
Medlemmar i forskargruppen
Gruppen leds av Karl Michaëlsson, professor i medicinsk epidemiologi och överläkare i ortopedisk kirurgi.
Gruppmedlemmar (kontaktinformation)
John Baron, professor
Hannah Brooke, docent, forskare
Liisa Byberg, professor
Marina Mola Caminal, föreståndare SIMPLER biobank
Carina Fredriksson, forskningssköterska
Emerald Heiland, postdoc
Jonas Höijer, statistiker
Anna-Karin Kolseth, projektkoordinator SIMPLER
Susanna Larsson, docent, universitetslektor
Eva Warensjö Lemming, docent, forskare
Karl Michaëlsson, professor
Erika Olsson, postdoc
Eva Strandberg, forskningssköterska
Bodil Svennblad, statistiker
Stanley Teleka, postdoc
Olga Titova, forskare
Doktorander
Mohammad Kharazmi: Bisphosphonate associated atypical fractures of the human skeleton
Anna Sprinchorn: Peroneus brevis and longus tendon tears – anatomy, injuries and treatment
Avhandlingar
Rui Zheng (2022): Metabolomics, body composition and fracture
Mikael Karlsson (2021): Diet and sarcopenia: Swedish cohort studies in ageing populations
Erika Olsson (2021): Dietary patterns, food groups and vitamin D in relation to dementia, cognitive impairment and Parkinson’s disease
Adam Mitchell (2020): The role of diabetes and glycemic traits in diabetic bone disease
Karl Stattin (2020): Physical activity and risk of fragility fractures
Björn Knutsson (2015): Body mass index and lumbar spinal stenosis
Breiffni Leavy (2015): Fall-Related Hip Fracture: Predisposing and Precipitating Factors
Helena Hallström (2013): Coffee Consumption in Relation to Osteoporosis and Fractures: Observational Studies in Men and Women
Helene Wagner (2012): Genetic and environmental influences on osteoporosis and fractures
Greta Snellman (2011): Boning up on vitamin D: Observational studies on bone and health
Bengt Östman (2009): Influence of oxidative stress on muscle and bone
Hans-Olov Hellström (2007): Bone and aluminium
Kurser och seminarier
Vi ger två årliga kurser på forskarnivå i medicinsk epidemiologi: en på grundläggande nivå (Introduction to epidemiology, 1,5 hp, kursansvarig Hannah Brooke) och en på intermediär till avancerad nivå (Medical epidemiology, 1,5 hp, kursansvarig Liisa Byberg). Med John Baron som huvudlärare erbjuder vi även ytterligare en kurs med inriktning mot klinisk epidemiologi och kliniska prövningar (Clinical Trials Epidemiology, kursansvarig Liisa Byberg). Information om alla våra kurser finns på sidan över kurser vid medicinska fakulteten: http://www2.medfarm.uu.se/utbildning/forskarniva/for_doktorander/kurser.html
Vi anordnar en seminarieserie dit doktorander vid Uppsala universitet är välkomna att diskutera epidemiologisk metod. Deltagande i 10 seminarier ger 1 hp. Mer information och schema för seminarieserien hittar du här (informationen finns endast på engelska).
Nätverk
Vi administrerar ett multidisciplinärt nätverk bestående av epidemiologer vid Uppsala universitet. Nätverket för seniora forskare är för närvarande aktivt endast i formen av en epostlista (du kan anmäla eller avanmäla dig till listan här).
Publikationer
Du hittar alla våra publikationer i Diva, de 50 senaste publikationerna finns listade nedan.
Karl Michaëlsson
Professor vid Institutionen för kirurgiska vetenskaper, Medicinsk epidemiologi
- E-post:
- Karl.Michaelsson[AT-tecken]surgsci.uu.se
- Telefon:
- 018-611 9545
50 senaste publikationerna
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Anti-inflammatory diet and incident peripheral artery disease: Two prospective cohort studies
Ingår i Clinical Nutrition, s. 1191-1196, 2022.
DOI för Anti-inflammatory diet and incident peripheral artery disease: Two prospective cohort studies Ladda ner fulltext (pdf) av Anti-inflammatory diet and incident peripheral artery disease: Two prospective cohort studies
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Can Small Amounts of Olive Oil Keep the Death Away?
Ingår i Journal of the American College of Cardiology, s. 113-115, 2022.
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Causal effect of renal function on venous thromboembolism: a two-sample Mendelian randomization investigation
Ingår i Journal of Thrombosis and Thrombolysis, s. 43-50, 2022.
DOI för Causal effect of renal function on venous thromboembolism: a two-sample Mendelian randomization investigation Ladda ner fulltext (pdf) av Causal effect of renal function on venous thromboembolism: a two-sample Mendelian randomization investigation
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Chlorination by-products in drinking water and risk of bladder cancer - A population-based cohort study
Ingår i Water Research, 2022.
DOI för Chlorination by-products in drinking water and risk of bladder cancer - A population-based cohort study Ladda ner fulltext (pdf) av Chlorination by-products in drinking water and risk of bladder cancer - A population-based cohort study
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Coffee and Caffeine Consumption and Risk of Kidney Stones: A Mendelian Randomization Study
Ingår i American Journal of Kidney Diseases, s. 9-14.e1, 2022.
DOI för Coffee and Caffeine Consumption and Risk of Kidney Stones: A Mendelian Randomization Study Ladda ner fulltext (pdf) av Coffee and Caffeine Consumption and Risk of Kidney Stones: A Mendelian Randomization Study
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Cohort profile: the Swedish study of SUDden cardiac Death in the Young (SUDDY) 2000-2010: a complete nationwide cohort of SCDs
Ingår i BMJ Open, 2022.
DOI för Cohort profile: the Swedish study of SUDden cardiac Death in the Young (SUDDY) 2000-2010: a complete nationwide cohort of SCDs Ladda ner fulltext (pdf) av Cohort profile: the Swedish study of SUDden cardiac Death in the Young (SUDDY) 2000-2010: a complete nationwide cohort of SCDs
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Development of gut microbiota during the first 2 years of life
Ingår i Scientific Reports, 2022.
DOI för Development of gut microbiota during the first 2 years of life
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Genetically Predicted Circulating Copper and Risk of Chronic Kidney Disease: A Mendelian Randomization Study
Ingår i Nutrients, s. 509-, 2022.
DOI för Genetically Predicted Circulating Copper and Risk of Chronic Kidney Disease: A Mendelian Randomization Study Ladda ner fulltext (pdf) av Genetically Predicted Circulating Copper and Risk of Chronic Kidney Disease: A Mendelian Randomization Study
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Health effects of high serum calcium levels: Updated phenome-wide Mendelian randomisation investigation and review of Mendelian randomisation studies
Ingår i EBioMedicine, 2022.
DOI för Health effects of high serum calcium levels: Updated phenome-wide Mendelian randomisation investigation and review of Mendelian randomisation studies Ladda ner fulltext (pdf) av Health effects of high serum calcium levels: Updated phenome-wide Mendelian randomisation investigation and review of Mendelian randomisation studies
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Leisure-time organised physical activity and dietary intake among Swedish adolescents
Ingår i Journal of Sports Sciences, s. 1-8, 2022.
DOI för Leisure-time organised physical activity and dietary intake among Swedish adolescents
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Long-term cadmium exposure and fractures, cardiovascular disease, and mortality in a prospective cohort of women
Ingår i Environment International, 2022.
DOI för Long-term cadmium exposure and fractures, cardiovascular disease, and mortality in a prospective cohort of women Ladda ner fulltext (pdf) av Long-term cadmium exposure and fractures, cardiovascular disease, and mortality in a prospective cohort of women
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Metabolic and lifestyle factors in relation to senile cataract: a Mendelian randomization study
Ingår i Scientific Reports, 2022.
DOI för Metabolic and lifestyle factors in relation to senile cataract: a Mendelian randomization study Ladda ner fulltext (pdf) av Metabolic and lifestyle factors in relation to senile cataract: a Mendelian randomization study
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Obesity, Type 2 Diabetes, Lifestyle Factors, and Risk of Gallstone Disease: A Mendelian Randomization Investigation
Ingår i Clinical Gastroenterology and Hepatology, s. E529-E537, 2022.
DOI för Obesity, Type 2 Diabetes, Lifestyle Factors, and Risk of Gallstone Disease: A Mendelian Randomization Investigation Ladda ner fulltext (pdf) av Obesity, Type 2 Diabetes, Lifestyle Factors, and Risk of Gallstone Disease: A Mendelian Randomization Investigation
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Plasma Caffeine Levels and Risk of Alzheimer's Disease and Parkinson's Disease: Mendelian Randomization Study
Ingår i Nutrients, 2022.
DOI för Plasma Caffeine Levels and Risk of Alzheimer's Disease and Parkinson's Disease: Mendelian Randomization Study Ladda ner fulltext (pdf) av Plasma Caffeine Levels and Risk of Alzheimer's Disease and Parkinson's Disease: Mendelian Randomization Study
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Risk of Revision After Arthroplasty Associated withSpecific Gene Loci: A Genomewide Association Study of Single-Nucleotide Polymorphisms in 1,130 TwinsTreated with Arthroplasty
Ingår i Journal of Bone and Joint Surgery, s. 610-620, 2022.
DOI för Risk of Revision After Arthroplasty Associated withSpecific Gene Loci: A Genomewide Association Study of Single-Nucleotide Polymorphisms in 1,130 TwinsTreated with Arthroplasty Ladda ner fulltext (pdf) av Risk of Revision After Arthroplasty Associated withSpecific Gene Loci: A Genomewide Association Study of Single-Nucleotide Polymorphisms in 1,130 TwinsTreated with Arthroplasty
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Selenium and cancer risk: Wide-angled Mendelian randomization analysis
Ingår i International Journal of Cancer, s. 1134-1140, 2022.
DOI för Selenium and cancer risk: Wide-angled Mendelian randomization analysis
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Serum levels of perfluoroalkyl substances (PFAS) and body composition - A cross-sectional study in a middle-aged population
Ingår i Environmental Research, s. 112677-, 2022.
DOI för Serum levels of perfluoroalkyl substances (PFAS) and body composition - A cross-sectional study in a middle-aged population Ladda ner fulltext (pdf) av Serum levels of perfluoroalkyl substances (PFAS) and body composition - A cross-sectional study in a middle-aged population
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The Effect of General Adiposity and Central Body Fat Distribution on the Circulating Metabolome: a Multi-Cohort Non-Targeted Metabolomics Observational and Mendelian Randomization Study
Ingår i Diabetes, s. 329-339, 2022.
DOI för The Effect of General Adiposity and Central Body Fat Distribution on the Circulating Metabolome: a Multi-Cohort Non-Targeted Metabolomics Observational and Mendelian Randomization Study Ladda ner fulltext (pdf) av The Effect of General Adiposity and Central Body Fat Distribution on the Circulating Metabolome: a Multi-Cohort Non-Targeted Metabolomics Observational and Mendelian Randomization Study
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The impact and causal directions for the associations between diagnosis of ADHD, socioeconomic status, and intelligence by use of a bi-directional two-sample Mendelian randomization design
Ingår i BMC Medicine, 2022.
DOI för The impact and causal directions for the associations between diagnosis of ADHD, socioeconomic status, and intelligence by use of a bi-directional two-sample Mendelian randomization design Ladda ner fulltext (pdf) av The impact and causal directions for the associations between diagnosis of ADHD, socioeconomic status, and intelligence by use of a bi-directional two-sample Mendelian randomization design
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The Nordic Nutrition Recommendations 2022: food consumption and nutrient intake in the adult population of the Nordic and Baltic countries
Ingår i Food & Nutrition Research, 2022.
DOI för The Nordic Nutrition Recommendations 2022: food consumption and nutrient intake in the adult population of the Nordic and Baltic countries Ladda ner fulltext (pdf) av The Nordic Nutrition Recommendations 2022: food consumption and nutrient intake in the adult population of the Nordic and Baltic countries
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Who makes it all the way?: Participants vs. decliners, and completers vs. drop-outs, in a 6-month exercise trial during cancer treatment. Results from the Phys-Can RCT
Ingår i Supportive Care in Cancer, s. 1739-1748, 2022.
DOI för Who makes it all the way?: Participants vs. decliners, and completers vs. drop-outs, in a 6-month exercise trial during cancer treatment. Results from the Phys-Can RCT Ladda ner fulltext (pdf) av Who makes it all the way?: Participants vs. decliners, and completers vs. drop-outs, in a 6-month exercise trial during cancer treatment. Results from the Phys-Can RCT
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A hypocaloric diet rich in high fiber rye foods causes greater reduction in body weight and body fat than a diet rich in refined wheat: A parallel randomized controlled trial in adults with overweight and obesity (the RyeWeight study)
Ingår i Clinical Nutrition, s. 155-169, 2021.
DOI för A hypocaloric diet rich in high fiber rye foods causes greater reduction in body weight and body fat than a diet rich in refined wheat: A parallel randomized controlled trial in adults with overweight and obesity (the RyeWeight study) Ladda ner fulltext (pdf) av A hypocaloric diet rich in high fiber rye foods causes greater reduction in body weight and body fat than a diet rich in refined wheat: A parallel randomized controlled trial in adults with overweight and obesity (the RyeWeight study)
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A posteriori Dietary Patterns in 71-year old Swedish Men and the Prevalence of Sarcopenia 16 Years Later
Ingår i British Journal of Nutrition, s. 1-28, 2021.
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Adaptation of the Charlson Comorbidity Index for Register-Based Research in Sweden
Ingår i Clinical Epidemiology, s. 21-41, 2021.
DOI för Adaptation of the Charlson Comorbidity Index for Register-Based Research in Sweden Ladda ner fulltext (pdf) av Adaptation of the Charlson Comorbidity Index for Register-Based Research in Sweden
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Alcohol consumption in relation to cardiovascular diseases and mortality: a systematic review of Mendelian randomization studies.
Ingår i European Journal of Epidemiology, 2021.
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An atlas on risk factors for multiple sclerosis: a Mendelian randomization study.
Ingår i Journal of Neurology, s. 114-124, 2021.
DOI för An atlas on risk factors for multiple sclerosis: a Mendelian randomization study. Ladda ner fulltext (pdf) av An atlas on risk factors for multiple sclerosis: a Mendelian randomization study.
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Anti-inflammatory diet and venous thromboembolism: Two prospective cohort studies
Ingår i NMCD. Nutrition Metabolism and Cardiovascular Diseases, s. 2831-2838, 2021.
DOI för Anti-inflammatory diet and venous thromboembolism: Two prospective cohort studies Ladda ner fulltext (pdf) av Anti-inflammatory diet and venous thromboembolism: Two prospective cohort studies
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Assessing causal associations of obesity and diabetes with kidney stones using Mendelian randomization analysis
Ingår i Molecular Genetics and Metabolism, s. 212-215, 2021.
DOI för Assessing causal associations of obesity and diabetes with kidney stones using Mendelian randomization analysis Ladda ner fulltext (pdf) av Assessing causal associations of obesity and diabetes with kidney stones using Mendelian randomization analysis
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Assessing the protective role of allergic disease in gastrointestinal tract cancers using Mendelian randomization analysis
Ingår i Allergy. European Journal of Allergy and Clinical Immunology, s. 1559-1562, 2021.
DOI för Assessing the protective role of allergic disease in gastrointestinal tract cancers using Mendelian randomization analysis Ladda ner fulltext (pdf) av Assessing the protective role of allergic disease in gastrointestinal tract cancers using Mendelian randomization analysis
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Assessing the role of cortisol in cancer: a wide-ranged Mendelian randomisation study
Ingår i British Journal of Cancer, s. 1025-1029, 2021.
DOI för Assessing the role of cortisol in cancer: a wide-ranged Mendelian randomisation study Ladda ner fulltext (pdf) av Assessing the role of cortisol in cancer: a wide-ranged Mendelian randomisation study
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Association between Cardiorespiratory Fitness and Circulating Proteins in 50-Year-Old Swedish Men and Women: a Cross-Sectional Study
Ingår i SPORTS MEDICINE-OPEN, 2021.
DOI för Association between Cardiorespiratory Fitness and Circulating Proteins in 50-Year-Old Swedish Men and Women: a Cross-Sectional Study Ladda ner fulltext (pdf) av Association between Cardiorespiratory Fitness and Circulating Proteins in 50-Year-Old Swedish Men and Women: a Cross-Sectional Study
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Association between pet ownership and sleep in the Swedish CArdioPulmonary bioImage Study (SCAPIS)
Ingår i Scientific Reports, 2021.
DOI för Association between pet ownership and sleep in the Swedish CArdioPulmonary bioImage Study (SCAPIS) Ladda ner fulltext (pdf) av Association between pet ownership and sleep in the Swedish CArdioPulmonary bioImage Study (SCAPIS)
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Association of food expenditure with life expectancy in the United States, 2001-2014.
Ingår i Nutrition (Burbank, Los Angeles County, Calif.), 2021.
DOI för Association of food expenditure with life expectancy in the United States, 2001-2014.
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Association of Serum Magnesium Levels With Risk of Intracranial Aneurysm: A Mendelian Randomization Study
Ingår i Neurology, s. E341-E344, 2021.
DOI för Association of Serum Magnesium Levels With Risk of Intracranial Aneurysm: A Mendelian Randomization Study Ladda ner fulltext (pdf) av Association of Serum Magnesium Levels With Risk of Intracranial Aneurysm: A Mendelian Randomization Study
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Associations of Total Legume, Pulse, and Soy Consumption with Incident Type 2 Diabetes: Federated Meta-Analysis of 27 Studies from Diverse World Regions
Ingår i Journal of Nutrition, s. 1231-1240, 2021.
DOI för Associations of Total Legume, Pulse, and Soy Consumption with Incident Type 2 Diabetes: Federated Meta-Analysis of 27 Studies from Diverse World Regions Ladda ner fulltext (pdf) av Associations of Total Legume, Pulse, and Soy Consumption with Incident Type 2 Diabetes: Federated Meta-Analysis of 27 Studies from Diverse World Regions
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Body Mass Index Differentially Moderates Heritability of Total Joint Replacement Due to Hip and Knee Osteoarthritis A Cohort Study of 29,893 Swedish Twin Pairs
Ingår i Journal of Bone and Joint Surgery. American volume, s. 1319-1327, 2021.
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Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study
Ingår i PLoS Medicine, 2021.
DOI för Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study Ladda ner fulltext (pdf) av Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study
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Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies
Ingår i BMC Medicine, 2021.
DOI för Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies Ladda ner fulltext (pdf) av Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies
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Changes in leisure-time physical activity during the adult life span and relations to cardiovascular risk factors-Results from multiple Swedish studies
Ingår i PLOS ONE, 2021.
DOI för Changes in leisure-time physical activity during the adult life span and relations to cardiovascular risk factors-Results from multiple Swedish studies Ladda ner fulltext (pdf) av Changes in leisure-time physical activity during the adult life span and relations to cardiovascular risk factors-Results from multiple Swedish studies
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Circulating Alpha-Tocopherol Levels, Bone Mineral Density, and Fracture: Mendelian Randomization Study
Ingår i Nutrients, 2021.
DOI för Circulating Alpha-Tocopherol Levels, Bone Mineral Density, and Fracture: Mendelian Randomization Study Ladda ner fulltext (pdf) av Circulating Alpha-Tocopherol Levels, Bone Mineral Density, and Fracture: Mendelian Randomization Study
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Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Ingår i BMC Medicine, 2021.
DOI för Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study Ladda ner fulltext (pdf) av Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
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Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study
Ingår i Nutrients, 2021.
DOI för Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study Ladda ner fulltext (pdf) av Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study
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Combinations of dietary calcium intake and mediterranean-style diet on risk of hip fracture: A longitudinal cohort study of 82,000 women and men
Ingår i Clinical Nutrition, s. 4161-4170, 2021.
DOI för Combinations of dietary calcium intake and mediterranean-style diet on risk of hip fracture: A longitudinal cohort study of 82,000 women and men Ladda ner fulltext (pdf) av Combinations of dietary calcium intake and mediterranean-style diet on risk of hip fracture: A longitudinal cohort study of 82,000 women and men
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Dairy foods, calcium, and risk of breast cancer overall and for subtypes defined by estrogen receptor status: a pooled analysis of 21 cohort studies
Ingår i American Journal of Clinical Nutrition, s. 450-461, 2021.